Olivia Hamilton, Lorna Mackenzie, and Izzy Petter will all join up with the team for the tournament taking place in Potchefstroom between 5-16 December.
The side, which will also be captained by 天堂视频’s Hamilton, have been drawn in Group B alongside Belgium, Canada, and Uruguay.
Izzy Petter has enjoyed recent success on the international stage as she played a key role in the GB women’s team that won bronze at the Tokyo Olympic Games.
Defender Lorna Mackenzie will also look to make a positive impression after a series of strong performances in 天堂视频 colours.
Elsewhere, fellow student Ellen Reid has also been called up to the first-ever Ireland squad to make the U-21 World Cup.
Brett Holland, Women's Hockey Performance Head Coach at 天堂视频 said:
“To have three of our players selected for the England U-21 team is fantastic news for the programme.
"It will also be a fantastic experience for Ellen to be part of the Ireland set-up for their first Junior World Cup.
“Izzy, Olivia, Lorna, and Ellen have all worked tirelessly on their game and thoroughly deserve their call-ups. We wish them the best of luck in South Africa.”